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Article

Immunization targeting a minor plaque constituent clears β-amyloid and rescues behavioral deficits in an Alzheimer's disease mouse model.

Neurobiology of aging - 1 Jan 2013

Morales-Corraliza Jose, Schmidt Stephen D, Mazzella Matthew J, Berger Jason D, Wilson Donald A, Wesson Daniel W, Jucker Mathias, Levy Efrat, Nixon Ralph A, Mathews Paul M

Abstract excerpt

Although anti-human β-amyloid (Aβ) immunotherapy clears brain β-amyloid plaques in Alzheimer's disease (AD), targeting additional brain plaque constituents to promote clearance has not been attempted. Endogenous murine Aβ is a minor Aβ plaque component in amyloid precursor protein (APP) transgeni...

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Identifiers

PMID: 22608241
DOI: 10.1016/j.neurobiolaging.2012.04.007
PMCID: PMC3426627

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APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22608241-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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