Article

Spatial Maps of Hepatocellular Carcinoma Transcriptomes Highlight an Unexplored Landscape of Heterogeneity and a Novel Gene Signature for Survival

2021-08-25

Abstract excerpt

<title>Abstract</title> <p><bold>Background: </bold>Hepatocellular carcinoma (HCC) are often present with satellite nodules, rendering current curative treatments ineffective in many patients. The heterogeneity of HCC is a major challenge in personalized medicine. The emergence of spatial transcriptomics (ST) provides a powerful strategy for delineating the complex molecular landscapes of tumors. <bold>Methods:</...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: eee54b62-988a-57e5-95d3-78247421da4d
DOI: 10.21203/rs.3.rs-812356/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Spatial Maps of Hepatocellular Carcinoma Transcriptomes Highlight an Unexplored Landscape of Heterogeneity and a Novel Gene Signature for SurvivalDOI 10.21203/rs.3.rs-812356/v1Read

Spatial maps of hepatocellular carcinoma transcriptomes highlight an unexplored landscape of heterogeneity and a novel gene signature for survivalSemantic proximity Read

HCCDB v2.0: Decompose the Expression Variations by Single-cell RNA-seq and Spatial Transcriptomics in HCCSemantic proximity Read

HCCDB v2.0: Decompose Expression Variations by Single-cell RNA-seq and Spatial Transcriptomics in HCCSemantic proximity Read

The spatial distribution and prognostic features of cell subtypes in primary hepatocellular carcinomaSemantic proximity Read

Understanding the heterogeneity in liver hepatocellular carcinoma with a special focus on malignant cell through single-cell analysisSemantic proximity Read

Spatial transcriptomics analysis of neoadjuvant cabozantinib and nivolumab in advanced hepatocellular carcinoma identifies independent mechanisms of resistance and recurrenceSemantic proximity Read

Multi-region spatial transcriptome analysis reveals cellular networks and pathways associated with hepatocellular carcinoma recurrenceSemantic proximity Read

Comprehensive Analysis of Spatial Architecture in Primary Liver CancerSemantic proximity Read

Deep Spatial Sequencing Revealing Differential Immune Responses in Human Hepatocellular CarcinomaSemantic proximity Read

Deciphering the heterogeneous niche in the tumor progression of hepatocellular carcinoma: a Spatial single-cell landscape and multi-omics atlas analysisSemantic proximity Read

spatialGE: Quantification and visualization of the tumor microenvironment heterogeneity using spatial transcriptomicsSemantic proximity Read

Mapping Heterogeneity of Hepatocellular Carcinoma by Investigating Hepatocyte-Specific Genes/TFs/Pathways Across Cellular and Tumor LandscapesSemantic proximity Read