Article

Predicting treatment-free remission outcomes in Chronic Myeloid Leukemia patients using an integrated model of tumor-immune dynamics

2024-10-12

Abstract excerpt

The interactions between tumor and the immune system are main factors in determining cancer treatment outcomes. In Chronic Myeloid Leukemia (CML), considerable evidence shows that the dynamics between residual leukemia and the patient’s immune system can result in either sustained disease control, leading to treatment-free remission (TFR), or disease recurrence. The question remains how to integrate mechanistic an...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0758e7a1-db5f-5199-aafe-17c94995ab63
DOI: 10.1101/2024.10.10.617526

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Predicting treatment-free remission outcomes in Chronic Myeloid Leukemia patients using an integrated model of tumor-immune dynamicsDOI 10.1101/2024.10.10.617526Read

To cure or not to cure: consequences of immunological interactions in CML treatmentSemantic proximity Read

Predictive nonlinear modeling of malignant myelopoiesis and tyrosine kinase inhibitor therapySemantic proximity Read

Dynamic modeling of imatinib-treated chronic myeloid leukemia: functional insights and clinical implicationsSemantic proximity Read

Early Dynamics of Chronic Myeloid Leukemia on Nilotinib Predicts Deep Molecular ResponseSemantic proximity Read

The ecology in the hematopoietic stem cell niche determines the clinical outcome in chronic myeloid leukemiaSemantic proximity Read

A computational model of CAR T-cell immunotherapy predicts leukemia patient responses at remission, resistance, and relapseSemantic proximity Read

Killer immunoglobulin-like receptors can predict TKI treatment-free remission in chronic myeloid leukemia patientsSemantic proximity Read

Mechanisms of Resistance to CAR-T cell Immunotherapy: Insights from a Mathematical ModelSemantic proximity Read

Rationale and motivating factors for treatment-free remission in chronic myeloid leukemia.Semantic proximity Read

Modeling and Simulation of CAR T cell Therapy in Chronic Lymphocytic Leukemia PatientsSemantic proximity Read

Mathematical Modeling of MPNs Offers Understanding and Decision Support for Personalized TreatmentSemantic proximity Read

Mathematical modelling of stem and progenitor cell dynamics during ruxolitinib treatment of patients with myeloproliferative neoplasmsSemantic proximity Read