Targeting Cathepsin-G to Overcome Leukemic Stem Cell Persistence in Chronic Myeloid

Abstract excerpt

<title>Abstract</title> <p> Chronic myeloid leukemia (CML) stem and progenitor cells (LSPCs) are not eliminated by tyrosine kinase inhibitors, resulting in disease relapse or progression. Transcriptomic profiling identified Cathepsin G ( <italic>CTSG</italic> ), a serine protease, as one of the top significantly upregulated targets in primary CML CD34 + cells compared to CD34 + cells from healthy donors (Log2...

Topics

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• Chronic Lymphocytic Leukemia Research
• Bone and Dental Protein Studies
• Chronic Myeloid Leukemia Treatments
• Eosinophilic Disorders and Syndromes
• Peptidase Inhibition and Analysis
• PI3K/AKT/mTOR signaling in cancer
• Protease and Inhibitor Mechanisms
• Quinazolinone synthesis and applications

Identifiers and source

Literature Corpus work

07407c81-0449-5325-8aa6-56ea4d83641d

DOI

10.21203/rs.3.rs-8580579/v1