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Article

GRIN2A Variants Associated With Idiopathic Generalized Epilepsies

14 Oct 2021

Abstract excerpt

Objective: The objective of this study is to explore the role of GRIN2A gene in idiopathic generalized epilepsies and the potential underlying mechanism for phenotypic variation. Methods: Whole-exome sequencing was performed in a cohort of 88 patients with idiopathic generalized epilepsies. Electro-physiological alterations of the recombinant N -methyl- D -aspartate receptors (NMDARs) containing GluN2A mutants...

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PMID: 34720871
DOI: 10.3389/fnmol.2021.720984

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