Article
Common variants in CLDN14 are associated with differential excretion of magnesium over calcium in urine.
Pflugers Archiv : European journal of physiology - 1 Jan 2017
Corre Tanguy, Olinger Eric, Harris Sarah E, Traglia Michela, Ulivi Sheila, Lenarduzzi Stefania, Belge Hendrica, Youhanna Sonia, Tokonami Natsuko, Bonny Olivier, Houillier Pascal, Polasek Ozren, Deary Ian J, Starr John M, Toniolo Daniela, Gasparini Paolo, Vollenweider Peter, Hayward Caroline, Bochud Murielle, Devuyst Olivier
Abstract excerpt
The nature and importance of genetic factors regulating the differential handling of Ca2+ and Mg2+ by the renal tubule in the general population are poorly defined. We conducted a genome-wide meta-analysis of urinary magnesium-to-calcium ratio to identify associated common genetic variants. We included 9320 adults of European descent from four genetic isolates and three urban cohorts. Urinary magnesium and...
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