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Article

Loss of insulin-induced activation of TRPM6 magnesium channels results in impaired glucose tolerance during pregnancy.

Proceedings of the National Academy of Sciences of the United States of America - 10 Jul 2012

Nair Anil V, Hocher Berthold, Verkaart Sjoerd, van Zeeland Femke, Pfab Thiemo, Slowinski Torsten, Chen You-Peng, Schlingmann Karl Peter, Schaller André, Gallati Sabina, Bindels René J, Konrad Martin, Hoenderop Joost G

Abstract excerpt

Hypomagnesemia affects insulin resistance and is a risk factor for diabetes mellitus type 2 (DM2) and gestational diabetes mellitus (GDM). Two single nucleotide polymorphisms (SNPs) in the epithelial magnesium channel TRPM6 (V(1393)I, K(1584)E) were predicted to confer susceptibility for DM2. Here, we show using patch clamp analysis and total internal reflection fluorescence microscopy, that insulin stimulates...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22733750
DOI: 10.1073/pnas.1113811109
PMCID: PMC3396482

Genes

TRPM6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Loss of insulin-induced activation of TRPM6 magnesium channels results in impaired glucose tolerance during pregnancy.PMID 22733750Read ↗

Common genetic variants of the ion channel transient receptor potential membrane melastatin 6 and 7 (TRPM6 and TRPM7), magnesium intake, and risk of type 2 diabetes in women.Semantic proximity Read ↗

Hypomagnesemia with secondary hypocalcemia is caused by mutations in TRPM6, a new member of the TRPM gene family.Semantic proximity Read ↗

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