Genome-Wide Meta-Analysis Unravels Interactions between Magnesium Homeostasis and Metabolic Phenotypes.

doi:10.1681/ASN.2017030267

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Article

Genome-Wide Meta-Analysis Unravels Interactions between Magnesium Homeostasis and Metabolic Phenotypes.

Journal of the American Society of Nephrology : JASN - 1 Jan 2018

Corre Tanguy, Arjona Francisco J, Hayward Caroline, Youhanna Sonia, de Baaij Jeroen H F, Belge Hendrica, Nägele Nadine, Debaix Huguette, Blanchard Maxime G, Traglia Michela, Harris Sarah E, Ulivi Sheila, Rueedi Rico, Lamparter David, Macé Aurélien, Sala Cinzia, Lenarduzzi Stefania, Ponte Belen, Pruijm Menno, Ackermann Daniel, Ehret Georg, Baptista Daniela, Polasek Ozren, Rudan Igor, Hurd Toby W, Hastie Nicholas D, Vitart Veronique, Waeber Geràrd, Kutalik Zoltán, Bergmann Sven, Vargas-Poussou Rosa, Konrad Martin, Gasparini Paolo, Deary Ian J, Starr John M, Toniolo Daniela, Vollenweider Peter, Hoenderop Joost G J, Bindels René J M, Bochud Murielle, Devuyst Olivier

Abstract excerpt

Magnesium (Mg2+) homeostasis is critical for metabolism. However, the genetic determinants of the renal handling of Mg2+, which is crucial for Mg2+ homeostasis, and the potential influence on metabolic traits in the general population are unknown. We obtained plasma and urine parameters from 9099 individuals from seven cohorts, and conducted a genome-wide meta-analysis of Mg2+ homeostasis. We identified two loci...

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PMID: 29093028
DOI: 10.1681/ASN.2017030267
PMCID: PMC5748908

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ARL15
TRPM6

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