Article

Bromelain and Ficin proteolytic effects on gliadin cytotoxicity and expression of genes involved in cell-tight junctions in Caco-2 cells

2023-08-01

Abstract excerpt

Enzyme therapy for Celiac disease (CeD), which digests gliadin into non-immunogenic and non-toxic peptides, can be an appropriate treatment option for CeD. Here we have investigated the effectiveness of Bromelain and Ficin on gliadin digestion using in vitro such as SDS-PAGE, HPLC, and circular dichroism (CD). Furthermore, the cytotoxicity of gliadin and 19-mer peptide before and after digestion with these enzymes...

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Literature Corpus work: 0705f5dc-b8f5-5612-a6c9-4fba28001815
DOI: 10.21203/rs.3.rs-3206070/v1

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Bromelain and Ficin proteolytic effects on gliadin cytotoxicity and expression of genes involved in cell-tight junctions in Caco-2 cellsDOI 10.21203/rs.3.rs-3206070/v1Read

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