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Article

Epithelial Transport of Immunogenic and Toxic Gliadin Peptides In Vitro

21 Nov 2014

Abstract excerpt

SCOPE: Celiac disease is an autoimmune disorder caused by failure of oral tolerance against gluten in genetically predisposed individuals. The epithelial translocation of gluten-derived gliadin peptides is an important pathogenetic step; the underlying mechanisms, however, are poorly understood. Thus, we investigated the degradation and epithelial translocation of two different gliadin peptides, the toxic P31-43...

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PMID: 25415429
DOI: 10.1371/journal.pone.0113932

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