Article

Divergent effects of target protein stabilisation versus overproduction on PROTAC activity

2026-04-18

Abstract excerpt

Protein degrader drugs such as PROTACs are being advanced as therapeutics targeted against oncogenic proteins. During tumorigenesis, oncogenic proteins can become constitutively activated via mechanisms including gene amplification, which increases protein production, and point mutations, which can extend protein half-life. Few experimental studies have addressed how disease-associated changes in target protein ho...

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Literature Corpus work: 070329a4-33a2-5615-9204-4e16f078458f
DOI: 10.64898/2026.04.15.718695

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