Article
The strategic roles of four enzymes in the interconnection between metabolism and oncogene activation in non-small cell lung cancer: Therapeutic implications.
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy - 1 Jul 2022
Icard Philippe, Simula Luca, Fournel Ludovic, Leroy Karen, Lupo Audrey, Damotte Diane, Charpentier Marie Christine, Durdux Catherine, Loi Mauro, Schussler Olivier, Chassagnon Guillaume, Coquerel Antoine, Lincet Hubert, De Pauw Vincent, Alifano Marco
Abstract excerpt
NSCLC is the leading cause of cancer mortality and represents a major challenge in cancer therapy. Intrinsic and acquired anticancer drug resistance are promoted by hypoxia and HIF-1α. Moreover, chemoresistance is sustained by the activation of key signaling pathways (such as RAS and its well-known downstream targets PI3K/AKT and MAPK) and several mutated oncogenes (including KRAS and EGFR among others). In this...
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