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Article

ACLY alternative splicing correlates with cancer phenotypes.

The Journal of biological chemistry - 1 Jul 2024

Supplee Julianna G, Affronti Hayley C, Duan Richard, Brooks Rebekah C, Stine Zachary E, Nguyen Phuong T T, Pinheiro Laura V, Noji Michael C, Drummond Jack M, Huang Kevin, Schultz Kollin, Dang Chi V, Marmorstein Ronen, Wellen Kathryn E

Abstract excerpt

ATP-citrate lyase (ACLY) links carbohydrate and lipid metabolism and provides nucleocytosolic acetyl-CoA for protein acetylation. ACLY has two major splice isoforms: the full-length canonical "long" isoform and an uncharacterized "short" isoform in which exon 14 is spliced out. Exon 14 encodes 10 amino acids within an intrinsically disordered region and includes at least one dynamically phosphorylated residue....

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Identifiers

PMID: 38815867
DOI: 10.1016/j.jbc.2024.107418
PMCID: PMC11260853

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