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Article

Capsid–host interactions for HIV-1 ingress

26 Sept 2023

Abstract excerpt

The HIV-1 capsid, composed of approximately 1,200 copies of the capsid protein, encases genomic RNA alongside viral nucleocapsid, reverse transcriptase, and integrase proteins. After cell entry, the capsid interacts with a myriad of host factors to traverse the cell cytoplasm, pass through the nuclear pore complex (NPC), and then traffic to chromosomal sites for viral DNA integration. Integration may very well...

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PMID: 37750702
DOI: 10.1128/mmbr.00048-22

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