Article

A low dose of naloxone mitigates autoimmune hepatitis by regulating TLR4/NF-κB and Nrf2/HO-1 signaling pathways

2023-05-04

Abstract excerpt

<title>Abstract</title> <p>Naloxone is a non-selective opiate receptor antagonist that is mainly used in the management of opiate addiction. Previously, naloxone has been shown to have anti-inflammatory and antioxidant properties. A popular and well-known animal model of autoimmune hepatitis that closely matches the pathogenic changes that take place in humans is the Concanavalin A (Con A) model. The present stud...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 06c81aa1-8db0-5831-8493-b3d7dd92f551
DOI: 10.21203/rs.3.rs-2873574/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A low dose of naloxone mitigates autoimmune hepatitis by regulating TLR4/NF-κB and Nrf2/HO-1 signaling pathwaysDOI 10.21203/rs.3.rs-2873574/v1Read

Innate Immunity and AlcoholSemantic proximity Read

Nerolidol: a potential approach in rheumatoid arthritis through reduction of TNF-α, IL-1β, IL-6, NF-Kβ, COX-2 and anti-oxidant effect in CFA-induced arthritic modelSemantic proximity Read

Comprehensive Biomarkers of Soman (GD)-induced Chronic Toxicity: Proinflammatory Cytokines, Oxidative Stress, and Organ Function ParametersSemantic proximity Read

The Inhibition of Nrf2/NQO1 pathway was involved in Polymyxin B Exerts Nephrotoxicity Effects in vivo and in vitroSemantic proximity Read

Protective effect of nimesulide against hepatic ischemia/reperfusion injury in rats: effects on oxidant/antioxidants, DNA mutation and COX-1/COX-2 levels.Semantic proximity Read

Naringin mitigates Bisphenol A-induced hepatotoxicity in cockerel chicksSemantic proximity Read

Inhibiting the TLR4-MyD88 signalling cascade by genetic or pharmacological strategies reduces acute alcohol-induced sedation and motor impairment in mice.Semantic proximity Read

A potential hepatoprotective effect of ranolazine against methotrexate-induced liver injury in ratsSemantic proximity Read

Investigating the effect of Zinc supplementation on the metabolic profile and expression of Nrf2, PPARγ and IL-10 genes in patients undergoing Methadone Maintenance Treatment: A Randomized, Double-Blind, Placebo- Controlled TrialSemantic proximity Read

Loss of BOK Has a Minor Impact on Acetaminophen Overdose-Induced Liver Damage in Mice.Semantic proximity Read

CXC receptor-2 knockout genotype increases X-linked inhibitor of apoptosis protein and protects mice from acetaminophen hepatotoxicity.Semantic proximity Read

Lipopolysaccharide (LPS) induced activation of the immune system in control rats and rats chronically exposed to a low level of the organothiophosphate insecticide, acephate.Semantic proximity Read