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The Inhibition of Nrf2/NQO1 pathway was involved in Polymyxin B Exerts Nephrotoxicity Effects in vivo and in vitro

2022-05-10

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<title>Abstract</title> <p>Polymyxin B (PMB) is a Polypeptide antibiotic widely applied in multidrug-resistant Gram-negative bacteria. However, nephrotoxicity is one of the serious adverse effects that limit its clinical use. Therefore, clarification of the molecular mechanism of PMB-induced renal injury appears to be particularly important. Our study aimed to explore the possible mechanism of PMB-induced nephrot...

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Literature Corpus work
a9d0b2d8-d3b7-570f-89e6-c99311d9b0f2
DOI
10.21203/rs.3.rs-1629876/v1
Open publication

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