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Article

Protective effect of nimesulide against hepatic ischemia/reperfusion injury in rats: effects on oxidant/antioxidants, DNA mutation and COX-1/COX-2 levels.

Pharmacological reports : PR - 1 Aug 2014

Demiryilmaz Ismail, Turan Mehmet Ibrahim, Kisaoglu Abdullah, Gulapoglu Mine, Yilmaz Ismayil, Suleyman Halis

Abstract excerpt

BACKGROUND: Nimesulide is a pharmacological agent and selective COX-2 inhibitor. It has anti-inflammatory, analgesic and antipyretic properties. The purpose of this study was to investigate the effect of nimesulide on oxidant/antioxidant, DNA mutation and COX-1/COX-2 activities in rat liver tissue with induced ischemia/reperfusion (I/R). METHODS: Before the experiment, rats were divided into four groups; liver...

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Identifiers

PMID: 24948067
DOI: 10.1016/j.pharep.2014.02.015

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MPO

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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