Article

TET2 drives 5hmc marking of <i>GATA6</i> and epigenetically defines pancreatic ductal adenocarcinoma transcriptional subtypes

2020-10-22

Abstract excerpt

<h4>Background and Aims</h4> Pancreatic ductal adenocarcinoma (PDAC) is characterised by advanced disease stage at presentation, aggressive disease biology and resistance to therapy resulting in extremely poor five-year survival <10%. PDAC is classified into transcriptional subtypes with distinct survival characteristics, although how these arise is not known. Epigenetic deregulation, rather than genetics, has be...

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Literature Corpus work: 06c49ee1-a2b5-5316-8869-d9fe284dd510
DOI: 10.1101/2020.10.22.342436

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