Article

Localization-dependent activation of the DEAD-box ATPase Vasa by eLOTUS domains

2026-03-29

Abstract excerpt

<h4>ABSTRACT</h4> DEAD-box RNA helicases remodel RNA structures in many cellular pathways, yet how their activity is spatially controlled in cells remains poorly understood. The Drosophila germline helicase Vasa functions in ovaries only when localized to cytoplasmic granules, a process mediated by eLOTUS-domain proteins. Here, we define the mechanism by which eLOTUS domains activate Vasa. Biochemical analyses r...

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Literature Corpus work: 06b94b9a-eed7-55c5-ad43-5ad308c0505c
DOI: 10.64898/2026.03.28.715021

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