Article

Inhibition of an immunometabolic axis of mTORC1 activation extends mammalian healthspan

2023-07-09

Abstract excerpt

Human ageing is associated with metabolic dysfunction, sarcopenia and frailty that taken together reduce healthspan. For age-associated diseases and lifespan, ERK, AMPK and mTORC1 represent critical pathways, across species 1–7 . Here we examined the hypothesis that IL11, recently shown to regulate ERK/mTORC1, is an inflammaging factor important for healthspan. As mice age, IL11 is progressively upregulated in li...

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Literature Corpus work: 06a0f6b1-b0d5-5d19-a3e0-338b81395352
DOI: 10.1101/2023.07.09.548250

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