Article

Maternal antibodies facilitate Amyloid-β clearance by activating Fc-receptor-Syk-mediated phagocytosis

2020-09-22

Abstract excerpt

Down Syndrome (DS) features a life-long overexpression of the APP and DYRK1A genes, leading to a cognitive decline mediated by Amyloid-β (Aβ) overproduction and tau hyper-phosphorylation. As DS can be diagnosed in utero, maternally transferred anti-Aβ antibodies might promote removal of early accumulation of Aβ from the CNS. A DNA-vaccine expressing Aβ 1-11 was delivered to wild-type female mice, followed by ma...

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Literature Corpus work: 0691df60-c4a0-5af6-b1a6-95a4071107eb
DOI: 10.1101/2020.09.22.296376

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