Article

Maternal synapsin 1 autoantibodies are associated with neurodevelopmental delay

2022-11-18

Abstract excerpt

Maternal autoantibodies can be transmitted diaplacentally, with potentially deleterious effects on neurodevelopment. Synapsin 1 (SYN1) is a neuronal protein that is important for synaptic communication and neuronal plasticity. While monoallelic loss of function (LoF) variants in the SYN1 gene result in X-linked intellectual disability (ID), learning disabilities, epilepsy, behavioral problems, and macrocephaly, th...

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Literature Corpus work: 390924a8-fe43-5731-829e-aba88b92c5c1
DOI: 10.1101/2022.11.17.22282130

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