PI5P4Kα Regulates Iron Balance to Promote Metabolic Fitness in Pancreatic Cancer

Abstract excerpt

Phosphoinositide kinases generate distinct phosphoinositides that regulate processes that maintain cellular fitness. Phosphatidylinositol 5-phosphate 4-kinases (PI5P4Ks) have garnered interest for their role in cancer metabolism and cellular trafficking; however, their function in pancreatic ductal adenocarcinoma (PDAC) remains unexplored. Given the unique metabolic demands of PDAC cells, which heavily rely on alt...

Topics

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• Autophagy in Disease and Therapy
• Cancer, Hypoxia, and Metabolism
• Carcinoma, Pancreatic Ductal
• Epigenetics and DNA Methylation
• Mutation
• Pancreatic and Hepatic Oncology Research
• Pancreatic Neoplasms
• Tumor Microenvironment

Identifiers and source

Literature Corpus work

0680627c-f866-58c4-b934-9b76d0b78842

DOI

10.1101/2025.04.07.647654