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Article

PI5P4Kα promotes glucose and iron acquisition to support metabolic fitness in pancreatic cancer

29 Aug 2025

Abstract excerpt

Phosphoinositide kinases generate distinct phosphoinositides that regulate pathways to support tumorigenesis. Phosphatidylinositol 5-phosphate 4-kinases (PI5P4Ks) have garnered interest for their role in cancer metabolism; however, their function in pancreatic ductal adenocarcinoma (PDAC) remains unexplored. We identify PI5P4Kα as a critical dependency to support the unique metabolic demands of PDAC cells through...

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PMID: 40884794
DOI: 10.1016/j.celrep.2025.116199

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