Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

NCOA4-Mediated Ferritinophagy Is a Pancreatic Cancer Dependency via Maintenance of Iron Bioavailability for Iron–Sulfur Cluster Proteins

30 Jun 2022

Abstract excerpt

Pancreatic ductal adenocarcinomas (PDAC) depend on autophagy for survival; however, the metabolic substrates that autophagy provides to drive PDAC progression are unclear. Ferritin, the cellular iron storage complex, is targeted for lysosomal degradation (ferritinophagy) by the selective autophagy adaptor NCOA4, resulting in release of iron for cellular utilization. Using patient-derived and murine models of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Ferroptosis and cancer prognosis
Share to Iron Metabolism and Disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35771492
DOI: 10.1158/2159-8290.cd-22-0043

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

NCOA4-Mediated Ferritinophagy Is a Pancreatic Cancer Dependency via Maintenance of Iron Bioavailability for Iron–Sulfur Cluster ProteinsPMID 35771492Read ↗

Autophagy supports mitochondrial metabolism through the regulation of iron homeostasis in pancreatic cancerSemantic proximity Read ↗

PI5P4Kα Regulates Iron Balance to Promote Metabolic Fitness in Pancreatic CancerSemantic proximity Read ↗

Iron and Lipocalin-2 Modulate Cellular Responses in the Tumor Micro-environment of Pancreatic Ductal AdenocarcinomaSemantic proximity Read ↗

Coordinated Transcriptional and Catabolic Programs Support Iron-Dependent Adaptation to RAS–MAPK Pathway Inhibition in Pancreatic CancerSemantic proximity Read ↗

COPZ1 regulates ferroptosis through NCOA4-mediated ferritinophagy in lung adenocarcinomaSemantic proximity Read ↗

Hepcidin-regulating iron metabolism genes and pancreatic ductal adenocarcinoma: a pathway analysis of genome-wide association studies.Semantic proximity Read ↗

Targeting pancreatic cancer glutamine dependency confers vulnerability to GPX4-dependent ferroptosisSemantic proximity Read ↗

Crosstalk between FTH1 and PYCR1 dysregulates proline metabolism and mediates cell growth in KRAS-mutant pancreatic cancer cells.Semantic proximity Read ↗

Pyruvate Kinase Activity Regulates Cystine Starvation Induced Ferroptosis through Malic Enzyme 1 in Pancreatic Cancer CellsSemantic proximity Read ↗

PI5P4Kα promotes glucose and iron acquisition to support metabolic fitness in pancreatic cancerSemantic proximity Read ↗

Alpha-Heredin targets CAMKⅡ/DRP1-Mediated mitochondrial fission to trigger ferroptosis in pancreatic ductal adenocarcinomaSemantic proximity Read ↗

Ferroptotic damage promotes pancreatic tumorigenesis through a TMEM173/STING-dependent DNA sensor pathwaySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.