Article

Evidence for a neuromuscular circuit involving hypothalamic Interleukin-6 signaling in the control of skeletal muscle metabolism

2021-07-29

Abstract excerpt

<title>Abstract</title> Hypothalamic interleukin-6 (IL6) exerts a broad metabolic control, including energy expenditure1, food consumption2, glucose homeostasis2, etc. Here we demonstrated that Interleukin-6 (IL6) activates the ERK1/2 pathway in the ventromedial hypothalamus (VMH), stimulating AMPK/ACC signaling and fatty acid oxidation in mice skeletal muscle. Bioinformatics a...

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Literature Corpus work: 066bef79-4f57-5603-b03d-9743f5e882f3
DOI: 10.21203/rs.3.rs-737420/v1

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