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Remodeling of purinergic signaling in the paraventricular hypothalamus promotes hyperphagic obesity and insulin resistance

2024-07-03

Abstract excerpt

<h4>ABSTRACT</h4> Body energy homeostasis is tightly regulated by hypothalamic neural circuits. However, their remodeling upon metabolic challenges remains incompletely characterized, thus complicating the development of safe medications against the surge of metabolic diseases. Oxytocin (OXT) neurons in the paraventricular nucleus of the hypothalamus (PVH) are one of the key effectors regulating energy balance. I...

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Literature Corpus work
77a44bb1-7e8e-533a-b573-2e1955bbf79f
DOI
10.1101/2024.07.02.601503
Open publication

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