Article

Germline Genetic NBN Variation and Predisposition to B-cell Acute Lymphoblastic Leukemia in Children

2023-07-21

Abstract excerpt

<title>Abstract</title> <p>Biallelic mutation in the DNA-damage repair gene <italic>NBN</italic> is the genetic cause of Nijmegen Breakage Syndrome, which is associated with predisposition to lymphoid malignancies. Heterozygous carriers of germline <italic>NBN</italic> variants may also be at risk for leukemia development, although this is much less characterized. We systematically examined the frequency of germl...

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Literature Corpus work: 064f4f18-994e-5fd8-818e-fc24ef4fc564
DOI: 10.21203/rs.3.rs-3171814/v1

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