Article

The molecular basis of hypercontractility caused by the hypertrophic cardiomyopathy mutations R403Q and R663H

2019-02-07

Abstract excerpt

Hypertrophic cardiomyopathy (HCM) mutations in ß-cardiac myosin and myosin binding protein-C (MyBP-C) cause hypercontractility of the heart. We show that hypercontractility caused by the HCM myosin mutation R663H cannot be explained by changes in the fundamental parameters such as actin-activated ATPase, intrinsic force, velocity of pure actin or regulated thin filaments, or the pCa50 of the velocity of regulated...

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Literature Corpus work: 064b093a-948e-5b01-b8b4-7bb01c2a4c96
DOI: 10.1101/543413

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