Article

Adoptive transfer of T lymphocytes retrovirally transduced to express personalized neoantigen reactive T cell receptors can mediate tumor regression in patients with metastatic colorectal cancer

2024-02-01

Abstract excerpt

<title>Abstract</title> <p>Adoptive cell transfer (ACT) using neoantigen reactive T lymphocytes can mediate cancer regression. Here, we developed methods to isolate unique, personalized, neoantigen reactive T cell receptors (TCRs) from tumor infiltrating lymphocytes (TIL) from patients with metastatic gastrointestinal cancers and incorporate the TCR α and β chains into gamma retroviral vectors. We transduced auto...

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Literature Corpus work: 0645a112-4262-57e8-86a8-eb878860acea
DOI: 10.21203/rs.3.rs-3888965/v1

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Adoptive transfer of T lymphocytes retrovirally transduced to express personalized neoantigen reactive T cell receptors can mediate tumor regression in patients with metastatic colorectal cancerDOI 10.21203/rs.3.rs-3888965/v1Read

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