Article
Differentiating erythroblasts adapt to turbulent flow by accelerating maturation and activating cholesterol biosynthesis
2023-12-08
Abstract excerpt
In vitro culture of erythroblasts (EBL) and production of mature erythrocytes for transfusions requires upscaling in fluidic-turbulent bioreactors, resulting in membrane shear stress. For the implementation of erythroid cultures in bioreactors, understanding the effects of mechanical stress on terminal EBL differentiation is required. To this end, we investigated the effect of orbital shaking-induced shear stress...
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Identifiers and source
- Literature Corpus work
- 0634285c-12a5-5bb8-b42e-872029570206
- DOI
- 10.1101/2023.12.08.570773