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Understanding mechanobiology in cultured endothelium: A review of the orbital shaker method

9 Apr 2019

Abstract excerpt

A striking feature of atherosclerosis is its highly non-uniform distribution within the arterial tree. This has been attributed to variation in the haemodynamic wall shear stress (WSS) experienced by endothelial cells, but the WSS characteristics that are important and the mechanisms by which they lead to disease remain subjects of intensive investigation despite decades of research. In vivo evidence suggests...

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PMID: 31096159
DOI: 10.1016/j.atherosclerosis.2019.04.210

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