Article

AMPKγ2 Deacetylation Drives Nuclear Translocation and Doxorubicin-Induced Cardiomyopathy via Nucleolar Stress Signaling

2026-07-16

Abstract excerpt

Doxorubicin (Dox)-induced cardiomyopathy (DIC), characterized by cardiomyocyte apoptosis, remains a major clinical challenge in chemotherapy. The regulatory γ2 subunit of AMP-activated protein kinase (AMPKγ2) plays a key role in cardiovascular diseases, but its function in DIC is poorly understood. Here, we report that Dox induces isoform-specific deacetylation and nuclear accumulation of γ2, triggering nucleolar...

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Literature Corpus work: 06295a6b-3869-58af-b346-12b10d07b93b
DOI: 10.64898/2026.07.16.737177

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AMPKγ2 Deacetylation Drives Nuclear Translocation and Doxorubicin-Induced Cardiomyopathy via Nucleolar Stress SignalingDOI 10.64898/2026.07.16.737177Read

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