Article

The Abl1 tyrosine kinase is a key player in doxorubicin-induced cardiomyopathy and its p53/p73 cell death mediated signaling differs in atrial and ventricular cardiomyocytes

2024-07-10

Abstract excerpt

<title>Abstract</title> <p>Background Doxorubicin is an important anticancer drug, however, elicits dose-dependently cardiomyopathy. Given its mode of action, i.e. topoisomerase inhibition and DNA damage, we investigated genetic events associated with cardiomyopathy and searched for mechanism-based possibilities to alleviate cardiotoxicity. We treated rats at clinically relevant doses of doxorubicin. Histopathol...

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Literature Corpus work: 93bd213f-8626-536d-9808-1d274d52bcb1
DOI: 10.21203/rs.3.rs-4571548/v1

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The Abl1 tyrosine kinase is a key player in doxorubicin-induced cardiomyopathy and its p53/p73 cell death mediated signaling differs in atrial and ventricular cardiomyocytesDOI 10.21203/rs.3.rs-4571548/v1Read

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