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Using the Connectivity Map to discover compounds influencing human osteoblast differentiation

1 Dec 2017

Abstract excerpt

Osteoporosis is a common skeletal disorder characterized by low bone mass leading to increased bone fragility and fracture susceptibility. Identification of factors influencing osteoblast differentiation and bone formation is very important. Previously, we identified parbendazole to be a novel compound that stimulates osteogenic differentiation of human mesenchymal stromal cells (hMSCs), using gene expression...

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PMID: 29194609
DOI: 10.1002/jcp.26298

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