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Article

Diverse CD8 T Cell Responses to Viral Infection Revealed by the Collaborative Cross.

Cell reports - 14 Apr 2020

Martin Matthew D, Sompallae Ramakrishna, Winborn Christina S, Harty John T, Badovinac Vladimir P

Abstract excerpt

Enhanced host protection against re-infection requires generation of memory T cells of sufficient quantity and functional quality. Unlike well-studied inbred mice, T cell responses of diverse size and quality are generated following infection of humans and outbred mice. Thus, additional models are needed that accurately reflect variation in immune outcomes in genetically diverse populations and to uncover...

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Identifiers

PMID: 32294433
DOI: 10.1016/j.celrep.2020.03.072
PMCID: PMC7212788

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