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Engineering probiotic <i>Escherichia coli</i> Nissle 1917 to block transfer of multiple antibiotic resistance genes by exploiting a type I CRISPR-Cas system

2024-04-02

Abstract excerpt

Many multidrug-resistant (MDR) bacteria evolved through accumulation of antibiotic-resistance genes (ARGs). Although the potential risk of probiotics as reservoirs of ARGs has been recognized, strategies for blocking transfer of ARGs while using probiotics have rarely been explored. The probiotic Escherichia coli Nissle 1917 (EcN) has long been used for treating intestinal diseases. Here, we showed frequent trans...

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Identifiers and source

Literature Corpus work
b958dd70-a506-54f7-ba8a-e100e6abbd0a
DOI
10.1101/2024.04.01.587504
Open publication

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Engineering probiotic <i>Escherichia coli</i> Nissle 1917 to block transfer of multiple antibiotic resistance genes by exploiting a type I CRISPR-Cas systemDOI 10.1101/2024.04.01.587504
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