Article

Interaction with tumor cell spheroids induces suppression in primary human cytotoxic T cells

2025-03-19

Abstract excerpt

Cytotoxic T lymphocytes (CTL) are key effectors in the anti-tumor immune response. However, their function is commonly suppressed in tumors in the form of exhausted CTL. Understanding molecular mechanisms of suppression and of therapeutics to overcome them is of substantial basic and translational importance yet hindered by limited access to large numbers of exhausted CTL in vitro. Here we use three-dimensional ti...

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Literature Corpus work: 05733a10-1686-585a-80a6-1e46daf1437d
DOI: 10.1101/2025.03.18.643973

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