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Article

3D live imaging and phenotyping of CAR-T cell mediated-cytotoxicity using high-throughput Bessel oblique plane microscopy.

Nature communications - 6 Aug 2024

Wang Zhaofei, Wang Jie, Zhao Yuxuan, Jin Jin, Si Wentian, Chen Longbiao, Zhang Man, Zhou Yao, Mao Shiqi, Zheng Chunhong, Zhang Yicheng, Chen Liting, Fei Peng

Abstract excerpt

Clarification of the cytotoxic function of T cells is crucial for understanding human immune responses and immunotherapy procedures. Here, we report a high-throughput Bessel oblique plane microscopy (HBOPM) platform capable of 3D live imaging and phenotyping of chimeric antigen receptor (CAR)-modified T-cell cytotoxicity against cancer cells. The HBOPM platform has the following characteristics: an isotropic...

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Identifiers

PMID: 39107283
DOI: 10.1038/s41467-024-51039-9
PMCID: PMC11303822

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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