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Article

Immunological Synapse Predicts Effectiveness of Chimeric Antigen Receptor Cells

2 Mar 2018

Abstract excerpt

Chimeric antigen receptor (CAR)-modified T cell therapy has the potential to improve the overall survival of patients with malignancies by enhancing the effectiveness of CAR T cells. Precisely predicting the effectiveness of various CAR T cells represents one of today's key unsolved problems in immunotherapy. Here, we predict the effectiveness of CAR-modified cells by evaluating the quality of the CAR-mediated...

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PMID: 29503199
DOI: 10.1016/j.ymthe.2018.01.020

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