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Cytotoxicity and infiltration of human NK cells in in vivo-like tumor spheroids

2 May 2015

Abstract excerpt

BACKGROUND: The complex cellular networks within tumors, the cytokine milieu, and tumor immune escape mechanisms affecting infiltration and anti-tumor activity of immune cells are of great interest to understand tumor formation and to decipher novel access points for cancer therapy. However, cellular in vitro assays, which rely on monolayer cultures of mammalian cell lines, neglect the three-dimensional...

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PMID: 25933805
DOI: 10.1186/s12885-015-1321-y

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