Article

Induced sensitization of tumor stroma leads to eradication of established cancer by T cells

2007-01-15

Abstract excerpt

Targeting cancer cells, as well as the nonmalignant stromal cells cross-presenting the tumor antigen (Ag), can lead to the complete destruction of well-established solid tumors by adoptively transferred Ag-specifi c cytotoxic T lymphocytes (CTLs).If, however, cancer cells express only low levels of the Ag, then stromal cells are not destroyed, and the tumor escapes as Ag loss variants.We show that treating well-es...

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Literature Corpus work: d9e06d9f-8aac-5143-a4cf-8b6741821ba9
DOI: 10.1083/jcb1762oia6

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