Article

α-Synuclein Triggers Intercellular Nanotubes Formation to Prevent Apoptosis in Astroglia by Promoting Stemness

2026-05-27

Abstract excerpt

Astrocytes play a significant role in neuroprotection by internalizing neurodegenerative aggregates and facilitating their degradation. Recent studies indicate that α-Synuclein (α-SYN) protofibrils promote the transfer of pathogenic aggregates and dysfunctional mitochondria between astroglia via tunneling nanotubes (TNTs), which enhances cell survival and resistance to apoptosis. However, the underlying mechanism...

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Literature Corpus work: 0562dd68-01b7-5b42-bddf-c7310da89d42
DOI: 10.64898/2026.05.23.727344

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