Article

Camouflaged Nanorobots Target and Drive the Subcellular Organelle Crosstalk Pattern of Innate Immune Cells to Promote Neural Regeneration

2025-07-22

Abstract excerpt

<title>Abstract</title> <p> Macrophage (Mφ) phenotypic transformation is crucial in determining spinal cord injury (SCI) outcomes. However, the suborganelle crosstalk mechanisms—particularly between the endoplasmic reticulum (ER) and mitochondria—that mediate Mφ subgroup conversion during SCI remain underexplored. We integrated niche intervention strategies and omics sequencing to investigate the effects of ER s...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 051e06bc-2800-5ecb-8d96-1c5ab49a3cf7
DOI: 10.21203/rs.3.rs-7023010/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Camouflaged Nanorobots Target and Drive the Subcellular Organelle Crosstalk Pattern of Innate Immune Cells to Promote Neural RegenerationDOI 10.21203/rs.3.rs-7023010/v1Read

Repair spinal cord injury with a versatile anti-oxidant and neural regenerative nanoplatformSemantic proximity Read

Amantadine modulates novel macrophage phenotypes to enhance neural repair following spinal cord injurySemantic proximity Read

Bone-Targeted SPIONs Mimicking Exercise-Induced Mechanical Stimulation to Activate Mitophagy and Suppress Osteocyte Senescence for Senile Osteoporosis TherapySemantic proximity Read

What’s New in Spinal Cord Injury Management: A Narrative Review on the Emerging Role of NanotechnologySemantic proximity Read

Immunomodulatory mechanisms of submicron phosphatidylserine-exposing polymeric particles (PSPs)Semantic proximity Read

Construction, Phenotypic Characterization, and Immunomodulatory Function Study of BMSC-Macrophage Hybrid in vitroSemantic proximity Read

SPIONs mediated magnetic actuation promotes nerve regeneration by inducing and maintaining repair-supportive phenotypes in Schwann cellsSemantic proximity Read

Advanced Therapies for Traumatic Central Nervous System Injury: Delivery Strategy Reinforced Efficient Microglial Manipulation.Semantic proximity Read

In vivo nanoneurotoxicity screening using oxidative stress and neuroinflammation paradigms.Semantic proximity Read

Single-cell sequencing reveals the optimal time window for anti-inflammatory treatment in spinal cord injurySemantic proximity Read

Magnetic nanocomplexes coupled with an external magnetic field modulate macrophage phenotype – a non-invasive strategy for bone regenerationSemantic proximity Read

Biomimetic Apoptotic Nanovesicles Derived from T Cells Target Neuroinflammation and Enhance Neural Regeneration via TGFBR2-Mediated Signaling for Spinal Cord Injury RepairSemantic proximity Read