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Article

Mesenchymal Stem Cells Stabilize Axonal Transports for Autophagic Clearance of α-Synuclein in Parkinsonian Models.

Stem cells (Dayton, Ohio) - 1 Aug 2017

Oh Se Hee, Lee Seok Cheol, Kim Dong Yeol, Kim Ha Na, Shin Jin Young, Ye Byoung Seok, Lee Phil Hyu

Abstract excerpt

Genome-wide association studies have identified two loci, SNCA and the microtubule (MT)-associated protein tau, as common risk factors for Parkinson's disease (PD). Specifically, α-synuclein directly destabilizes MT via tau phosphorylation and induces axonal transport deficits that are the primary events leading to an abnormal accumulation of α-synuclein that causes nigral dopaminergic cell loss. In this study,...

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Identifiers

PMID: 28580639
DOI: 10.1002/stem.2650

Genes

SNCA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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