Article

Loss of Elp1 disrupts trigeminal ganglion neurodevelopment in a model of Familial Dysautonomia

2021-06-10

Abstract excerpt

Familial Dysautonomia (FD) is a sensory and autonomic neuropathy caused by a mutation in Elongator complex protein 1 ( ELP1 ). FD patients have small trigeminal nerves and impaired perception of facial pain and temperature. These signals are relayed by nociceptive neurons in the trigeminal ganglion, a structure comprised of both neural crest- and placode-derived cells. Mice lacking Elp1 in neural crest derivati...

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Literature Corpus work: d4e723fd-27b7-5de4-a8c4-b781e3164a55
DOI: 10.1101/2021.06.10.447739

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