Article

“Generation of two Betacellulin CRISPR-Cas9 knockout hiPSC lines to study affected EGF system paradigm in Schizophrenia”

2025-04-09

Abstract excerpt

Several members of the epidermal growth factor (EGF) family have been implicated in the biology of schizophrenia (Ketharanathan et al., 2024). The EGF-related ligand, Betacellulin (BTC), plays an important role in the proliferation and differentiation of neural stem cells and our group found markedly reduced BTC levels in patients with schizophrenia. Nevertheless, the interplay of affected BTC and its participatio...

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Literature Corpus work: 053064f6-9fed-5e06-a09d-f9d9eee47dde
DOI: 10.1101/2025.04.07.647671

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