Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Amantadine modulates novel macrophage phenotypes to enhance neural repair following spinal cord injury.

Journal of translational medicine - 13 Jan 2025

Yang Shijie, Yu Beibei, Zhang Qing, Zhang Yongfeng, Fu Longhui, Zhou Bisheng, Wu Haining, Li Jianzhong, Gong Shouping

Abstract excerpt

BACKGROUND: Spinal cord injury (SCI) triggers a complex inflammatory response that impedes neural repair and functional recovery. The modulation of macrophage phenotypes is thus considered a promising therapeutic strategy to mitigate inflammation and promote regeneration. METHODS: We employed microarray and single-cell RNA sequencing (scRNA-seq) to investigate gene expression changes and immune cell dynamics in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Nerve injury and regeneration
Share to Neuroinflammation and Neurodegeneration Mechanisms

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Spinal Cord Injury Research

Source

Open in PubMed Open full text

Identifiers

PMID: 39806436
DOI: 10.1186/s12967-024-05916-y
PMCID: PMC11726942

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 22 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Amantadine modulates novel macrophage phenotypes to enhance neural repair following spinal cord injury.PMID 39806436Read ↗

Single-cell sequencing reveals the optimal time window for anti-inflammatory treatment in spinal cord injurySemantic proximity Read ↗

Managing inflammation after spinal cord injury through manipulation of macrophage function.Semantic proximity Read ↗

Redefining macrophage phenotypes after spinal cord injury: An open data approach.Semantic proximity Read ↗

Cell-type-specific m1A dynamics are associated with microglial phenotypic transition and neuronal metabolic adaptation during spinal cord injury.Semantic proximity Read ↗

SARM1 promotes neuroinflammation and inhibits neural regeneration after spinal cord injurySemantic proximity Read ↗

Elevated phagocytic capacity directs innate spinal cord repairSemantic proximity Read ↗

Research Progress on Treating Spinal Cord Injury by Modulating the Phenotype of Microglia.Semantic proximity Read ↗

P2Y12-targeted modulation of microglial phenotypes: A novel therapeutic strategy for enhanced axonal regeneration post-spinal cord injury.Semantic proximity Read ↗

Identification of Differentially Expressed Genes in Spinal Cord InjurySemantic proximity Read ↗

Activation of Neuroprotective Microglia and Astrocytes at the Lesion Site and in the Adjacent Segments Is Crucial for Spontaneous Locomotor Recovery after Spinal Cord Injury.Semantic proximity Read ↗

LSP1 in Spinal Cord Injury: Acute Inflammation-Related Biomarker and Potential Therapeutic TargetSemantic proximity Read ↗

Single-cell sequencing for the molecular identity involved in zinc therapy for spinal cord injurySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.