Amantadine modulates novel macrophage phenotypes to enhance neural repair following spinal cord injury

Abstract excerpt

Spinal cord injury (SCI) triggers a complex inflammatory response that impedes neural repair and functional recovery. The modulation of macrophage phenotypes is thus considered a promising therapeutic strategy to mitigate inflammation and promote regeneration. We employed microarray and single-cell RNA sequencing (scRNA-seq) to investigate gene expression changes and immune cell dynamics in mice following crush...

Topics

Join the communities discussing this publication.

• Nerve injury and regeneration
• Neuroinflammation and Neurodegeneration Mechanisms
• Spinal Cord Injury Research