Article
In vivo nanoneurotoxicity screening using oxidative stress and neuroinflammation paradigms.
Nanomedicine : nanotechnology, biology, and medicine - 1 Oct 2013
Kim Youngsoon, Kong Seong Deok, Chen Li-Han, Pisanic Thomas R, Jin Sungho, Shubayev Veronica I
Abstract excerpt
Iron oxide nanoparticles (IONPs) are promising neuroimaging agents and molecular cargo across neurovascular barriers. Development of intrinsically safe IONP chemistries requires a robust in vivo nanoneurotoxicity screening model. Herein, we engineered four IONPs of different surface and core chemistries: DMSA-Fe2O3, DMSA-Fe3O4, PEG-Fe3O4 and PEG-Au-Fe3O4. Capitalizing on the ability of the peripheral nervous...
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