Article

The Multivariate Normal Distribution Framework for Analyzing Association Studies

2017-10-28

Abstract excerpt

Genome-wide association studies (GWAS) have discovered thousands of variants involved in common human diseases. In these studies, frequencies of genetic variants are compared between a cohort of individuals with a disease (cases) and a cohort of healthy individuals (controls). Any variant that has a significantly different frequency between the two cohorts is considered an associated variant. A challenge in the an...

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Literature Corpus work: 04ff079d-fb6b-5939-a087-1d28f8e1d385
DOI: 10.1101/208199

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